A practical guide for the preparation of C1-labeled α-amino acids using aldehyde catalysis with isotopically labeled CO2

Michael G. J. Doyle, Braeden A. Mair, Anna Sib, Odey Bsharat, Maxime Munch, Volker Derdau, Benjamin H. Rotstein, Rylan J. Lundgren

Published: 2024-03-28 DOI: 10.1038/s41596-024-00974-4

C1-labeling

alpha-amino acids

isotopic labeling

carboxylate exchange

aldehyde catalysis

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Sections

Figures

References

Introduction
Materials
Procedure 1: preparation of (±)-[1-13C]phenylalanine
- Part 1: setup and reaction period
- Part 2: workup and purification
Procedure 2: preparation of (±)-[1-11C]phenylalanine
Procedure 3: preparation of (±)-[1-14C]phenylalanine
- Part 1: setup and reaction period
- Part 2: workup and purification
Troubleshooting
Timing
Anticipated results
Acknowledgements

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A practical guide for the preparation of C1-labeled α-amino acids using aldehyde catalysis with isotopically labeled CO2

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