Identification of cancer-related mutations in human pluripotent stem cells using RNA-seq analysis

Elyad Lezmi, Nissim Benvenisty

Published: 2021-08-05 DOI: 10.1038/s41596-021-00591-5

human pluripotent stem cells

quality control

RNA-seq analysis

cancer-related mutations

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Single-cell RNA sequencing (scRNA-seq)（单细胞RNA测序）

Data integration（数据集成）

Heterogeneity（异质性）

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Human pluripotent stem cells (hPSCs) are known to acquire genetic aberrations during invitro propagation. In addition to recurrent chromosomal aberrations, it has recently been shown that these cells also gain point mutations in cancer-related genes, pre
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ACKNOWLEDGMENTS

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Identification of cancer-related mutations in human pluripotent stem cells using RNA-seq analysis

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