Reconstructing phylogenetic trees from genome-wide somatic mutations in clonal samples

Tim H. H. Coorens, Inigo Martincorena, Peter J. Campbell, Michael Spencer Chapman, Nicholas Williams, Michael R. Stratton, Jyoti Nangalia

Published: 2024-02-23 DOI: 10.1038/s41596-024-00962-8

somatic mutations

phylogenetic tree reconstruction

clonal samples

Sequoia pipeline

single-cell DNA sequencing

AI 解读

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Genome-wide quantification of transcription factor binding at single-DNA-molecule resolution using methyl-transferase footprinting

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Decoding personal biotic and abiotic airborne exposome

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Single-cell RNA sequencing (scRNA-seq)（单细胞RNA测序）

Data integration（数据集成）

Heterogeneity（异质性）

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References

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Reconstructing phylogenetic trees from genome-wide somatic mutations in clonal samples

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