Single-cell RNA and protein profiling of immune cells from the mouse brain and its border tissues

Yvan Saeys, Isabelle Scheyltjens, Hannah Van Hove, Karen De Vlaminck, Daliya Kancheva, Jonathan Bastos, Mónica Vara-Pérez, Ana Rita Pombo Antunes, Liesbet Martens, Charlotte L. Scott, Jo A. Van Ginderachter, Martin Guilliams, Niels Vandamme, Kiavash Movahedi

Published: 2022-08-04 DOI: 10.1038/s41596-022-00716-4

single-cell RNA sequencing

immune cell profiling

CITE-seq

neuroinflammation

brain immune landscape

AI 解读

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Scanorama: integrating large and diverse single-cell transcriptomic datasets

Single-cell RNA sequencing (scRNA-seq)（单细胞RNA测序）

Data integration（数据集成）

Heterogeneity（异质性）

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Brain–nobreakimmune cross-talk and neuroinflammation critically shape brain physiology in health and disease. A detailed understanding of the brain immune landscape is essential for developing new treatments for neurological disorders. Single-cell
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ACKNOWLEDGMENTS

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Single-cell RNA and protein profiling of immune cells from the mouse brain and its border tissues

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