Directed differentiation of ureteric bud and collecting duct organoids from human pluripotent stem cells

Min Shi, Ping Fu, Joseph V. Bonventre, Kyle W. McCracken

Published: 2023-07-16 DOI: 10.1038/s41596-023-00847-2

Ureteric Bud Organoids

Human Pluripotent Stem Cells

Collecting Duct Differentiation

Kidney Development Model

Branching Morphogenesis

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Ransick, A. et al. Single-cell profiling reveals sex, lineage, and regional diversity in the mouse kidney. Dev. Cell 51, 399–413 e397 (2019).
Park, J. et al. Single-cell transcriptomics of the mouse kidney reveals potential cellular targets of kidney disease. Science 360, 758–763 (2018).
England, A. R. et al. Identification and characterization of cellular heterogeneity within the developing renal interstitium. Development 147, dev190108 (2020).
Daniel, E. et al. Spatiotemporal heterogeneity and patterning of developing renal blood vessels. Angiogenesis 21, 617–634 (2018).
Munro, D. A. D., Hohenstein, P. & Davies, J. A. Cycles of vascular plexus formation within the nephrogenic zone of the developing mouse kidney. Sci. Rep. 7, 3273 (2017).
Barak, H., Rosenfelder, L., Schultheiss, T. M. & Reshef, R. Cell fate specification along the anterior–posterior axis of the intermediate mesoderm. Dev. Dyn. 232, 901–914 (2005).
Taguchi, A. et al. Redefining the in vivo origin of metanephric nephron progenitors enables generation of complex kidney structures from pluripotent stem cells. Cell Stem Cell 14, 53–67 (2014).
Costantini, F. Genetic controls and cellular behaviors in branching morphogenesis of the renal collecting system. Wiley Interdiscip. Rev. Dev. Biol. 1, 693–713 (2012).
Kobayashi, A. et al. Six2 defines and regulates a multipotent self-renewing nephron progenitor population throughout mammalian kidney development. Cell Stem Cell 3, 169–181 (2008).
Morizane, R. et al. Nephron organoids derived from human pluripotent stem cells model kidney development and injury. Nat. Biotechnol. 33, 1193–1200 (2015).
Takasato, M. et al. Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis. Nature 526, 564–568 (2015).
Tsujimoto, H. et al. A modular differentiation system maps multiple human kidney lineages from pluripotent stem cells. Cell Rep. 31, 107476 (2020).
Howden, S. E. et al. Plasticity of distal nephron epithelia from human kidney organoids enables the induction of ureteric tip and stalk. Cell Stem Cell 28, 671–684 e676 (2021).
Mae, S. I. et al. Generation of branching ureteric bud tissues from human pluripotent stem cells. Biochem. Biophys. Res. Commun. 495, 954–961 (2018).
Mae, S. I. et al. Expansion of human iPSC-derived ureteric bud organoids with repeated branching potential. Cell Rep. 32, 107963 (2020).
Taguchi, A. & Nishinakamura, R. Higher-order kidney organogenesis from pluripotent stem cells. Cell Stem Cell 21, 730–746 e736 (2017).
Zeng, Z. et al. Generation of patterned kidney organoids that recapitulate the adult kidney collecting duct system from expandable ureteric bud progenitors. Nat. Commun. 12, 3641 (2021).
Shi, M. et al. Human ureteric bud organoids recapitulate branching morphogenesis and differentiate into functional collecting duct cell types. Nat. Biotechnol. 41, 252–261 (2023).
Sawada, K. & Aoyama, H. Fate maps of the primitive streak in chick and quail embryo: ingression timing of progenitor cells of each rostro-caudal axial level of somites. Int. J. Dev. Biol. 43, 809–815 (1999).
Parameswaran, M. & Tam, P. P. Regionalisation of cell fate and morphogenetic movement of the mesoderm during mouse gastrulation. Dev. Genet 17, 16–28 (1995).
Attia, L., Yelin, R. & Schultheiss, T. M. Analysis of nephric duct specification in the avian embryo. Development 139, 4143–4151 (2012).
Przepiorski, A. et al. A simple bioreactor-based method to generate kidney organoids from pluripotent stem cells. Stem Cell Rep. 11, 470–484 (2018).
Morizane, R. & Bonventre, J. V. Generation of nephron progenitor cells and kidney organoids from human pluripotent stem cells. Nat. Protoc. 12, 195–207 (2017).
Sanchez-Ferras, O. et al. A coordinated progression of progenitor cell states initiates urinary tract development. Nat. Commun. 12, 2627 (2021).
Pepicelli, C. V., Kispert, A., Rowitch, D. H. & McMahon, A. P. GDNF induces branching and increased cell proliferation in the ureter of the mouse. Dev. Biol. 192, 193–198 (1997).
Vega, Q. C., Worby, C. A., Lechner, M. S., Dixon, J. E. & Dressler, G. R. Glial cell line-derived neurotrophic factor activates the receptor tyrosine kinase RET and promotes kidney morphogenesis. Proc. Natl Acad. Sci. USA 93, 10657–10661 (1996).
Michos, O. et al. Kidney development in the absence of Gdnf and Spry1 requires Fgf10. PLoS Genet. 6, e1000809 (2010).
Qiao, J., Sakurai, H. & Nigam, S. K. Branching morphogenesis independent of mesenchymal-epithelial contact in the developing kidney. Proc. Natl Acad. Sci. USA 96, 7330–7335 (1999).
Yuri, S., Nishikawa, M., Yanagawa, N., Jo, O. D. & Yanagawa, N. In vitro propagation and branching morphogenesis from single ureteric bud cells. Stem Cell Rep. 8, 401–416 (2017).
Toka, H. R., Toka, O., Hariri, A. & Nguyen, H. T. Congenital anomalies of kidney and urinary tract. Semin. Nephrol. 30, 374–386 (2010).
Kuure, S. & Sariola, H. Mouse models of congenital kidney anomalies. Adv. Exp. Med. Biol. 1236, 109–136 (2020).
Grobstein, C. Inductive epitheliomesenchymal interaction in cultured organ rudiments of the mouse. Science 118, 52–55 (1953).
Broda, T. R., McCracken, K. W. & Wells, J. M. Generation of human antral and fundic gastric organoids from pluripotent stem cells. Nat. Protoc. 14, 28–50 (2019).
McCracken, K. W., Howell, J. C., Wells, J. M. & Spence, J. R. Generating human intestinal tissue from pluripotent stem cells in vitro. Nat. Protoc. 6, 1920–1928 (2011).
Spence, J. R. et al. Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro. Nature 470, 105–109 (2011).
McCracken, K. W. et al. Modelling human development and disease in pluripotent stem-cell-derived gastric organoids. Nature 516, 400–404 (2014).

Directed differentiation of ureteric bud and collecting duct organoids from human pluripotent stem cells

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